{"id":11844,"date":"2021-03-29T01:36:48","date_gmt":"2021-03-29T08:36:48","guid":{"rendered":"https:\/\/worldcampaign.net\/?p=11844"},"modified":"2021-03-29T01:36:48","modified_gmt":"2021-03-29T08:36:48","slug":"how-mary-wortley-montagus-bold-experiment-led-to-smallpox-vaccine-75-years-before-jenner-the-observer","status":"publish","type":"post","link":"https:\/\/worldcampaign.net\/?p=11844","title":{"rendered":"&#8220;How Mary Wortley Montagu&#8217;s bold experiment led to smallpox vaccine \u2013 75 years before Jenner&#8221;, The Observer"},"content":{"rendered":"<p>Donna Ferguson, London,\u00a028 Mar 2021<\/p>\n<div class=\"css-zjgnrw\">\n<div class=\"css-xmt4aq\" data-print-layout=\"hide\">\n<p>A new book celebrates the trailblazing work of the English aristocrat, who successfully inoculated her daughter<\/p>\n<\/div>\n<\/div>\n<div class=\"css-pn0kqp\">\n<div class=\"css-krkkhw\">\n<div class=\"css-nzznp8\">\n<figure>\n<div class=\"css-1nfcn93\">\n<div class=\"css-1nfcn93\"><picture><source srcset=\"https:\/\/i.guim.co.uk\/img\/media\/5ea81592982d720b42f8dad8b771f6cb52f246c5\/84_633_3514_2109\/master\/3514.jpg?width=620&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=c8b624eb664f2d50f3f26be2dc3bce84 1240w,https:\/\/i.guim.co.uk\/img\/media\/5ea81592982d720b42f8dad8b771f6cb52f246c5\/84_633_3514_2109\/master\/3514.jpg?width=605&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=d3b99f4ed837138561e02dc0cc5a816e 1210w,https:\/\/i.guim.co.uk\/img\/media\/5ea81592982d720b42f8dad8b771f6cb52f246c5\/84_633_3514_2109\/master\/3514.jpg?width=445&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=7fca28eb00bff050be5f058cccd2609f 890w\" media=\"(-webkit-min-device-pixel-ratio: 1.25), (min-resolution: 120dpi)\" sizes=\"(min-width: 660px) 620px, 100vw\" \/><source srcset=\"https:\/\/i.guim.co.uk\/img\/media\/5ea81592982d720b42f8dad8b771f6cb52f246c5\/84_633_3514_2109\/master\/3514.jpg?width=620&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=509cf819cea6e1034c13b3755f21ce2c 620w,https:\/\/i.guim.co.uk\/img\/media\/5ea81592982d720b42f8dad8b771f6cb52f246c5\/84_633_3514_2109\/master\/3514.jpg?width=605&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=acb66319d602aa1a8a612a556027682c 605w,https:\/\/i.guim.co.uk\/img\/media\/5ea81592982d720b42f8dad8b771f6cb52f246c5\/84_633_3514_2109\/master\/3514.jpg?width=445&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=dddf2a86aa0ecc97c3802c7ac9ddddd5 445w\" sizes=\"(min-width: 660px) 620px, 100vw\" \/><img loading=\"lazy\" decoding=\"async\" class=\"css-uk6cul\" src=\"https:\/\/i.guim.co.uk\/img\/media\/5ea81592982d720b42f8dad8b771f6cb52f246c5\/84_633_3514_2109\/master\/3514.jpg?width=445&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=7fca28eb00bff050be5f058cccd2609f\" alt=\"Edward Jenner administering a smallpox vaccine to a child\" width=\"2000\" height=\"1200\" \/><\/picture><\/div>\n<\/div><figcaption class=\"css-xe26t6\"><span class=\"css-19x4pdv\">Edward Jenner administering a smallpox vaccine. He himself had been inoculated as a child by doctors following Lady Mary Wortley Montagu\u2019s ideas.<\/span> Photograph: Getty<\/figcaption><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"css-1aul2ye\">\n<div class=\"css-krkkhw\">\n<div class=\"css-15ibrj7\">\n<div class=\"css-a6edhj\">\n<div class=\"article-body-commercial-selector css-79elbk article-body-viewer-selector\">\n<p class=\"css-6ebghe\">It was a daring and dangerous experiment that paved the way for the development of the first safe vaccine and saved countless lives. Yet when <a href=\"https:\/\/www.theguardian.com\/books\/2016\/aug\/18\/letter-by-mary-wortley-montagu-pioneering-travel-writer-up-for-auction\" data-link-name=\"in body link\">Lady Mary Wortley Montagu<\/a> deliberately infected her own daughter with a tiny dose of <a title=\"\" href=\"https:\/\/www.theguardian.com\/science\/2020\/jul\/23\/researchers-find-earliest-confirmed-case-smallpox-viking-era\" data-link-name=\"in body link\">smallpox<\/a> \u2013 successfully inoculating the three-year-old child in 1721 \u2013 her ideas were dismissed and she was denounced by 18th-century society as an \u201cignorant woman\u201d .<\/p>\n<p class=\"css-6ebghe\">Three hundred years later, on the anniversary of that first groundbreaking inoculation on English soil, a new biography will aim to raise the profile of Wortley Montagu and reassert her rightful place in history as a trailblazing 18th-century scientist and early feminist.<\/p>\n<p class=\"css-6ebghe\">\u201cIf she had not inoculated her daughter, we would not then have gone on ultimately to find a cure for smallpox,\u201d said Jo Willett, author of <em><a title=\"\" href=\"https:\/\/www.pen-and-sword.co.uk\/The-Pioneering-Life-of-Mary-Wortley-Montagu-Hardback\/p\/18797\" data-link-name=\"in body link\">The Pioneering Life of Mary Wortley Montagu<\/a><\/em>, which will be published on Tuesday. \u201cShe should be heralded for that \u2013 yet she\u2019s not really well known, and I think partly that\u2019s because she was a woman.\u201d<\/p>\n<p class=\"css-6ebghe\">Wortley Montagu, a <a title=\"\" href=\"https:\/\/www.theguardian.com\/science\/2020\/nov\/21\/it-was-a-total-invasion-the-virus-that-came-back-from-the-dead\" data-link-name=\"in body link\">smallpox<\/a> survivor with a disfigured face, took the risky decision to inoculate her daughter by making tiny cuts on her daughter\u2019s skin and rubbing in a small amount of pus from a live smallpox sore.<\/p>\n<aside class=\"css-1kl3axy\"><\/aside>\n<p class=\"css-6ebghe\">This gave the child, known as \u201cyoung Mary\u201d, a very mild dose of the disease, Willett said. \u201cNormally, with smallpox, you might have several thousand spots on your body. An inoculated child would probably have about 30 spots and then a few days later they\u2019d be absolutely fine again, running around and having fun.\u201d<\/p>\n<p class=\"css-6ebghe\">Wortley Montagu had learned about the practice of inoculation in Turkey, where her husband had worked as the British ambassador. \u201cWhen she got there, she went to Turkish baths and saw women without any smallpox marks on their skin. That was a wake-up call.\u201d<\/p>\n<div id=\"dfp-ad--inline1\" class=\"js-ad-slot ad-slot ad-slot--inline ad-slot--inline1 ad-slot--outstream ad-slot--rendered\" data-link-name=\"ad slot inline1\" data-name=\"inline1\" data-mobile=\"1,1|2,2|300,197|300,250|300,274|fluid\" data-phablet=\"1,1|2,2|300,197|300,250|300,274|620,350|550,310|fluid\" data-desktop=\"1,1|2,2|300,250|300,274|620,1|620,350|550,310|fluid\" data-google-query-id=\"CKKq_v-K1e8CFbCUpwodDewFPg\">\n<div class=\"ad-slot__label\"><\/div>\n<p class=\"css-6ebghe\">In 18th-century Turkey, inoculation was a common \u201cfolk practice\u201d, typically carried out by \u201cilliterate old Greek and Armenian women\u201d, Willett said. \u201cShe asked them about it and analysed it, and decided it was worth the risk.\u201d<\/p>\n<p class=\"css-6ebghe\">She managed to successfully inoculate her son while she was there, but her daughter was too young. The family then returned to England, where Wortley Montagu\u2019s enthusiasm for inoculation was met with suspicion and strong resistance from the medical establishment. \u201cWhen Lady Mary first came back, she didn\u2019t dare do anything [to her daughter]. But there was such a severe outbreak in 1721, she thought she had to take action.\u201d<\/p>\n<p class=\"css-6ebghe\">She then invited highly respected physicians and \u201cladies of distinction\u201d round to witness young Mary\u2019s speedy recovery from the infection. One of the physicians who visited was so convinced, he decided to inoculate his own son, which also went well. Young Mary soon became famous. \u201cNews reached Princess Caroline, who was the Princess of Wales at the time. She took up the cause and eventually the royal children were inoculated. Word spread that it was a good thing to do.\u201d<\/p>\n<p class=\"css-6ebghe\">However, not everyone was convinced. \u201cThe Whigs were pro-inoculation but the Tory party was really against it \u2013 a lot of Tories wrote about how it was interfering with nature and it was dangerous. It became very politicised.\u201d<\/p>\n<figure class=\"css-1sioudk\">\n<div class=\"css-1nfcn93\"><picture><source srcset=\"https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=380&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=6c497ad5a0a1c1f1b901e4f54d6397e5 760w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=300&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=883c6fe23e48ced3807660d94e509cfb 600w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=620&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=6522201bed53a0bd6115d36be1f8634a 1240w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=605&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=f3b8865f37a873078d37c08ea1072fb5 1210w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=445&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=84f710e07d5026a6e944e2f83f49a9f1 890w\" media=\"(-webkit-min-device-pixel-ratio: 1.25), (min-resolution: 120dpi)\" sizes=\"(min-width: 1300px) 380px, 300px\" \/><source srcset=\"https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=380&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=ee93cb85a03d926f4a1fe0f4bf716b80 380w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=300&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=ced3eb2bcc307b710f1bec43f2ee7985 300w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=620&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=ecf472a4aa8c1ec0d13fc460367665f0 620w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=605&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=764e77f2a0fb456d96ad67f7c986a256 605w,https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=445&amp;quality=85&amp;auto=format&amp;fit=max&amp;s=8175df51942e48c66ecaa65566197143 445w\" sizes=\"(min-width: 1300px) 380px, 300px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"css-uk6cul\" src=\"https:\/\/i.guim.co.uk\/img\/media\/f133ee63eca80618e0c0e0faf06967ee7b3dc348\/0_0_4305_5315\/master\/4305.jpg?width=300&amp;quality=45&amp;auto=format&amp;fit=max&amp;dpr=2&amp;s=883c6fe23e48ced3807660d94e509cfb\" alt=\"Lady Mary Wortley Montagu, painted by Joseph Highmore\" width=\"4305\" height=\"5315\" \/><\/picture><\/div><figcaption class=\"css-zq9xdq\"><span class=\"css-19x4pdv\">Lady Mary Wortley Montagu, painted by Joseph Highmore, got the idea for inoculation after seeing the practice in Turkey.<\/span> Photograph: Getty<\/figcaption><\/figure>\n<p class=\"css-6ebghe\">Sometimes people died from smallpox after the procedure, which had to be carried out very carefully to ensure only a small dose was administered. \u201cOften the gashes were too big.\u201d In Turkey, people knew they needed to self-isolate for a period after an inoculation, but in England the process was \u2018medicalised\u2019 by ill-informed physicians. They pointlessly purged and bled their patients during the inoculation, and then allowed people to walk around while they were infectious, unwittingly spreading the disease. \u201cThere was a lot of misinformation.\u201d<\/p>\n<p class=\"css-6ebghe\">As controversy mounted, Wortley Montagu\u2019s reputation suffered and her argument \u2013 that the inoculation process should not be medicalised \u2013 was dismissed. One prominent physician, William Wagstaffe, bemoaned the fact that a practice performed by a \u201cfew ignorant women\u201d was being adopted in the royal palace, while Alexander Pope wrote venomous poems about Wortley Montagu, describing her as \u201cpoxed\u201d. \u201cHe knew people would know she was connected to smallpox, but by using the word \u2018pox\u2019, he was implying that she had syphilis. So that didn\u2019t help her reputation.\u201d<\/p>\n<div id=\"dfp-ad--inline2\" class=\"js-ad-slot ad-slot ad-slot--inline ad-slot--offset-right ad-slot--inline2 ad-slot--sky ad-slot--rendered\" data-link-name=\"ad slot inline2\" data-name=\"inline2\" data-mobile=\"1,1|2,2|300,197|300,250|300,274|fluid\" data-phablet=\"1,1|2,2|300,197|300,250|300,274|620,350|550,310|fluid\" data-desktop=\"1,1|2,2|300,250|300,274|620,1|620,350|550,310|fluid|300,600|160,600\" data-google-query-id=\"CNm8882L1e8CFWyDfwQdXS8FUw\"><\/div>\n<p class=\"css-6ebghe\">Young Mary wrote that she remembers servants giving her \u201cdark looks\u201d and acting as if they were repulsed by her when she visited aristocratic families with her mother to inoculate the household.<\/p>\n<p class=\"css-6ebghe\">When Edward Jenner invented the smallpox vaccine in 1796, by taking fluid from a cowpox vaccine and scratching it on to the skin of a young boy, he was building on Wortley Montagu\u2019s discovery, Willett said. \u201cShe brought a cure to the west. And that cure was developed into what we now think of as vaccination.\u201d<\/p>\n<figure id=\"cef83542-5223-47b4-af4d-504d77e4b18c\" class=\"css-1mfia18\">\n<div class=\"css-1i4v9dy\" data-print-layout=\"hide\" data-link-name=\"rich-link-0 | 0\" data-component=\"rich-link\" data-name=\"\"><\/div>\n<\/figure>\n<p class=\"css-6ebghe\">As a child, Jenner had himself been inoculated against smallpox by doctors following in Wortley Montagu\u2019s footsteps. \u201cHe went through the whole purging and bleeding process and had such a grim experience that I think he thought: \u2018there has to be an easier way of doing this\u2019.\u201d<\/p>\n<p class=\"css-6ebghe\">When he realised that dairymaids never got smallpox, he \u201cmade the leap\u201d and thought of introducing cowpox pus into a scratch instead of smallpox pus. \u201cIf he hadn\u2019t been inoculated, then I don\u2019t think he would have gone on to think about vaccination,\u201d says Willett.<\/p>\n<p class=\"css-6ebghe\">Jenner had discovered a much safer way to confer immunity \u2013 and, unlike Wortley Montagu, as an educated male physician, he could publish scientific papers about his discovery and be taken seriously. He was later credited by Louis Pasteur as the discoverer of the first vaccine. \u201cOften in the canon of the history of science, women get overlooked,\u201d said Willett. \u201cLady Mary is one of those women.\u201d<\/p>\n<p class=\"css-6ebghe\"><a href=\"https:\/\/www.theguardian.com\/society\/2021\/mar\/28\/how-mary-wortley-montagus-bold-experiment-led-to-smallpox-vaccine-75-years-before-jenner\">The Observer<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Donna Ferguson, London,\u00a028 Mar 2021 A new book celebrates the trailblazing work of the English aristocrat, who successfully inoculated her daughter Edward Jenner administering a smallpox vaccine. He himself had been inoculated as a child by doctors following Lady Mary Wortley Montagu\u2019s ideas. Photograph: Getty It was a daring and dangerous experiment that paved the [&hellip;]<\/p>\n","protected":false},"author":1001004,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"_links":{"self":[{"href":"https:\/\/worldcampaign.net\/index.php?rest_route=\/wp\/v2\/posts\/11844"}],"collection":[{"href":"https:\/\/worldcampaign.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/worldcampaign.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/worldcampaign.net\/index.php?rest_route=\/wp\/v2\/users\/1001004"}],"replies":[{"embeddable":true,"href":"https:\/\/worldcampaign.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11844"}],"version-history":[{"count":1,"href":"https:\/\/worldcampaign.net\/index.php?rest_route=\/wp\/v2\/posts\/11844\/revisions"}],"predecessor-version":[{"id":11845,"href":"https:\/\/worldcampaign.net\/index.php?rest_route=\/wp\/v2\/posts\/11844\/revisions\/11845"}],"wp:attachment":[{"href":"https:\/\/worldcampaign.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/worldcampaign.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/worldcampaign.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}